ABSTRACT
Objective:To explore changes of oxidized loW density lipoprotein (ox-LDL)and tumor necrosis factor (TNF)-αcontent in patients With different degrees coronary heart disease (CHD)and their correlation.Methods:A total of 100 CHD patients diagnosed by coronary angiography (CAG)Were selected and divided into stable angina pectoris (SAP)group (n=23),unstable angina pectoris (UAP)group (n=48)and acute myocardial infarction (AMI)group (n=29);single vessel group (n=31),double vessel group (n=33)and multi-vessel disease group (n=36);mild stenosis group (n=27), moderate stenosis group (n=31)and severe stenosis group (n=42).A total of 30 middle-aged and aged people Without CHD and severe organic diseases,Were enrolled as healthy control group.Content of total cholesterol (TC),triglyceride(TG),high density lipoprotein cholesterol (HDL-C),loW density lipoprotein cholesterol (LDL-C),ox-LDL and TNF-α Were measured among above groups.Results:Compared With healthy control group,there Were significant increase in blood lipid levels (except HDL-C),TNF-αlevel,and significant decrease in HDL-C level in CHD group,P <0.05 all; compared With SAP group,thereWere significant increase in levels of ox-LDL and TNF-αin UAP group and AMI group (P <0.05 all),and those of AMI groupWere significantly higher than those of UAP group (P <0.05 both);comparedWith single vessel disease group,there Were significant increase in levels of ox-LDL [(432.19±80.75)μg/L vs.(560.47± 84.21)μg/L,(619.31±88.49)μg/L]and TNF-α[(9.01±2.75)ng/L vs.(10.06±2.78)ng/L,(11.14±2.74)ng/L] in double-vessel and multi-vessel disease group (P <0.05 all),and those of multi-vessel disease group Were significantly higher than those of double-vessel disease group (P <0.05 both);comparedWith mild stenosis group,thereWere significant increase in levels of ox-LDL [(459.43±53.36)μg/L vs.(531.33±68.12)μg/L,(610.62±93.43)μg/L]and TNF-α[(8.98±2.66)ng/L vs.(9.94±2.87)ng/L,(11.12±3.21)ng/L]in moderate stenosis group and severe stenosis group (P <0.05 all),and those of severe stenosis groupWere significantly higher than those of moderate stenosis group (P <0.05 both);Spearman correlation analysis indicated that ox-LDL levelWas positively correlatedWith TNF-αlevel (r =0.83,P <0.01).Conclusion:Levels of ox-LDL and TNF-αare closely correlatedWith lesion severity in CHD patients.